I have the DP comfort seat and have no problems riding all day. I find that by the time I need to take a break and stretch is about the same time I need to stop for fuel. The HM is the most comfortable bike I have ever owned.
+1. So far 400 mile days of all backroads no problem. GPS to find gas and a couple 2L emergency cans in a tail bag (never used) and its fine for any east coast sport touring.