You might break into the riding position a bit....
Two of the most uncomfortable bikes I've ridden are the Ducati 1098 and the Aprilia RSV.
The S10000RR is WAY more comfortable in comparison. After a week of commuting on the S1 I found myself getting used to the position and felt like my body was adjusting.
Week two I could handle a 4 hour ride, when initially, a half hour started to piss me off.
Now I wonder if I could get used to something as extreme as a 1098, I think probably.