FIL had a 5th wheel dually for several years, and liked it just fine for their lifestyle at the time, before my MIL got ill (she passed 3 years ago).
Now, he and his new lady friend are getting back into travel, and downsized a bit. They bought an ultra light, 30' drag trailer with one slide, and an F-150 to pull it.
The Ford is a crew cab, V-6 with tow package, and weight distributing hitch setup. The truck alone gets low-20s; and low to mid teens towing.
So far, they towed it home a couple of hundred miles, another trip to Arkansas and back (300-ish each way), and then to south Texas for the winter. He said that other than being a bit more susceptiple to winds and long grades, it's working just fine for them.