The great thing about nationals is there is always factory support. I would just ask Dale what the top guys are running for the specific conditions. I would bring a range of main jets down to include a 118 and 116 main and the smaller pilots you mentioned. You will also need to tweak the air screw. Verifying Plug color and listening for detonation up a big/steep hill are good things double check after you go leaner. (a hard throttle chop near the top of the hill will also verify the air screw setting)
Good luck in Co.