I have owned both and the Tiger is no longer in my stable. The Tiger is a very good road bike that you can take off road. Off road it never felt right, I always felt like it was going to break! The Tenere is a 575 lb enduro that excels off road. As others have mentioned it's size is a bit intimidating at first and picking it up can be a chore. The good news is the more experience you have on the S10 pig, your skills improve and the amount of time spent picking it up becomes a non issue. For me it boils down to learning to trust this big bike's capabilities and going with it.!
2014 Honda CRF250L
2013 Husky TR 650