Might be a bit South for you. But the missus and I did a micro brewery tour last 4th of July. Nine breweries in five days.
Most were within walking distance of a place to stay.
http://www.advrider.com/forums/showthread.php?t=807378
Cities visited were Chattanooga, TN; Bryson City, NC; Ashville, NC; Knowville, TN; and Nashville, TN.
Had a great time from what I remember.