Lots of good suggestions here.....the FZ6, Versys, Vstrom, and many of the others sound great....but, I'll still go with the trusty KLR for many of the reasons mentioned before.
I've got 61,000 miles on my '06 model, one valve adjustment at 45,000, and I can change the oil and filter before I even take my helmet and gloves off....inexpensive, simple, and bullet-proof.
I commute 54 miles one way, with interstate and backroad options....it works well either route. Now I have changed the rear shock, fork springs/valving, and added a fork brace, they aren't perfect in stock form like some of the others may be.
Good luck with your decision.
2013 Yamaha Super Tenere(the new girl in town)
'06 Kawasaki KLR650(72,000+ miles)
'04 Honda XR400
'76 Yamaha TY250