Makes no difference at all
I'll be killed just as badly on my GL1800 950 pound Goldwing as I will on my 650 KLR or my vintage 350f Honda. I suppose there's SOME minor difference in that the GL1800 has more power and better brakes etc., but a left-turner or bimbo on her cellphone ramming me from behind at a light will kill the shit out of me no matter what I'm on. I really don't consider the bike I'm on a factor at all when street riding (OK, if I'm on my CT90 I know that's a powerless brakeless shitbox for modern roadway travel, but I don't ride it in city conditions. It's only for gravel roads and very rural pavement where it's rare to see more than a few cars).