I won't go as far as to say I get panic attacks when I drive a "cage" after using the bike 95% of the time.
I do get a little uncomfortable and I more or less refuse to drive my wife's car unless for some reason I have to. Feel really closed in and like I can't see anything.
In my truck, I feel like I'm taking up the entire road and can't fit anywhere. Takes me 10 minutes or so of driving to get readjusted to driving it. When I get back on the bike I almost let out a sigh of relief because I'm out in the open again.
I ride 652ccs of slug.