To unpack the bags all you need to do is open the roll top and pull your stuff out. To make it a bit easier to get your stuff out... and the best way to reload the bags... is to loosen the strap that goes over the seat (one cam buckle), loosen the two cinch straps (one strap adjuster for each cinch strap) and release the three side release buckles (one on each end of the roll top and one strap over the roll top). The bags can absolutely stay on the bike. If you did decide to remove the bags they would come off the bike (and go back on) in less time than the Coyote IMO. The bags have the same liner that is found in all of the US bags. I think that if the bags were on the bike empty they would cinch up ok... but you would have a lot of extra strap to stow. They are not really designed to empty though and they go on and come off so easily there is no reason to leave them on empty.