I'm still of the mindset that 6.5mm is overkill for varmint work - including coyotes. Double duece bullets are a lot cheaper and with the right combination will shoot just as flat as any 6 or 6.5mm. You'll get a little more wind drift with the 22 but that's easily accounted for. For me the best all-around, do-all varmint cartridge is the .22-250 Ackley Improved with a fast (1-8") twist barrel. I can shoot most anything from a 45 to 80 grain bullet, I can shoot factory 22-250 ammo in a pinch so I don't "have to" handload everything, and barrel life is still fairly reasonable at around 2 to 3k rounds before the accuracy starts to fall off. My long-range prairie dog/coyote load is pushing an 80 grain Nosler at 3,380fps. With a 200 yard zero my drop at 1,000 yards is only 21.6 minutes (verified) at an elevation of 3,300 ft. Wind drift is 7.3 MOA @ 1,000yds (calculated) with a 10mph/90-degree crosswind. My standard every day load (pretty much anything out to 500 yards) uses a 65 grain Sierra Gameking bullet propelled to 3,725fps. This particular bullet was originally designed for the Australian market for use on kangaroo's and it hits like a sledgehammer. Great bullet for you southern deer or hog hunters using a .224 cal cartridge.