It will be a taxing ride on a fully loaded tiger, when I did it we went east to west (supposedly the harder way). To clarify it was my father inlaws bike but he crashed a few times in the first 20km and broke himself so I took over. I found the hardest section was west of the SA border. Some bright spark thought it would be a good idea to put turns in the track both up and down and also at the top of the dunes, this was by and far the hardest bit of the whole trip, there were a few times when I got beached just due to not being able to carry enough speed to keep ontop of the sand, I would make sure that you have enough strength to repeatedly pull/dig your bike out of a up hill beaching. I would have a shovel of some to dig yourself out. I am guessing you can ride fairly well otherwise you wouldnt even consider something like this. I think we budgeted about 44ltrs fuel for birdsville to oodnadatta and we had a bit spare at the end but you will have figure out your own safety calculation. How much spare fuel and water can you carry on your setup? We had the standard original tyres which were ok but I think something with more grip would make a better time of it in the deep sand. We ended up pushing the radiator back a bit from a few slow offs which then forced the fan to rub on the core which then led to 5 small leaks which we fixed with quick metal. When you get to the big salt lake that runs north south try to limit the the amount of fun, I wound it up a bit too much and ran out of track and ended up 50m into a very soft clay pan. I would have a hand held uhf and some way to charging it, whilst most of the time you can see a few dunes ahead it did help knowing how many were in the convoy. How many days are you planning to take, obviously you will travel alot faster than cars. Once the sun starts to dip it is almost impossible to see your line in the shadows. Once you cross into QLD I think it gets easier as the tracks go straight up and down the dunes meaning you can carry more speed. We went in June and there was only a few times I took off the mesh jacket but I think in April it will be a bit hotter. Be prepared to be wacked on the arm/leg repeatedly from the the track side trees, the width is a 4wd so your arm just glances each and every tree/bush, between dunes you can carry some high speed if you want to but it is nice to recover a bit.