I personally have no more issues with my Tenere than I do any other bike I ever had. I also have issues with my hands as I have worked with them my whole life and they are definitely showing signs of wear. I agree with Mark that using a throttle lock or rocker can help a lot with grip..which for me seems to be the bigger problem. Vibrations are like buffeting, seats, bars, peg relations..it really depends on the individual and there sensitivity levels. We all have different things that bother us at different levels.. I say buy the bike, see what you think, make a few minor adjustments if needed. If that doesn't work then sell the bike and move on, there are lots of great bikes out there.